E-AB-14978
EID1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-14978
- Additional Names:
- 21 kDa pRb associated protein,21 kDa pRb-associated protein,C15orf3,CBP,CREBBP/EP300 inhibitor 1,CREBBP/EP300 inhibitory protein 1,CRI 1,CRI1,Chromosome 15 open reading frame 3,E1A like inhibitor of differentiation,E1A-like inhibitor of differentiation 1
- Application:
- IHC
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human EID1
- Uniprot:
- Q9Y6B2
- Synonyms:
- 21 kDa pRb-associated protein;C15orf3;CREBBP/EP300 inhibitor 1;CREBBP/EP300 inhibitory protein 1;CRI1;E1A-like inhibitor of differentiation 1;EID-1;EP300-interacting inhibitor of differentiation 1;IRO45620;NB4 apoptosis related protein;PNAS-22;PTD014;Rb- and p300-binding protein EID-1;RBP21;retinoblastoma protein-associated protein
- Extra Details:
- E1A-like inhibitor of differentiation-1 (EID-1), an acetyltransferase enzyme, binds both the retinoblastoma protein (Rb), a regulator of cell cycle and tissue specific transcription, and the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. EID-1 inhibits cellular differentiation by blocking the histone acetyltransferase activity of p300. EID-1 also acetylates both histones and non-histone proteins such as NCOA3 co-activator. By acetylating histones, EID-1 gives a specific tag for transcriptional activation. In addition to binding Rb and p300, EID-1 also binds to phosphorylated CREB protein, mediating cAMP gene regulation. EID-1 augments the activity of phosphorylated CREB and activates transcription of cAMP responsive genes as a co-activator.
- Shipping Conditions:
- Blue Ice