DCTN4 Polyclonal Antibody

Size

£106.20

Was £118.00

SKU:: E-AB-14938
Additional Names:: DCTN 4,DCTN4,Dctn4,Dynactin 4,Dynactin 4 (p62),Dynactin p62 subunit,Dynactin subunit 4,Dynactin subunit p62,Dynactin4,p62
Application:: IHC
Concentration:: 0.6 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant protein of human DCTN4
Uniprot:: Q9UJW0
Synonyms:: DYN4;dynactin 4 (p62);dynactin p62 subunit;dynactin subunit 4;dynactin subunit p62;P62
Extra Details:: Dynactin is a multisubunit complex and a required cofactor for most, or all, of the cellular processes powered by the microtubule-based motor cytoplasmic dynein . Dynactin contains a short actin-related protein 1 (Arp1) filament with capZ at the barbed end and p62 at the pointed end . The p62 subunit is an integral component of 20 S dynactin with a highly conserved cysteine-rich motif that interacts directly with Arp1. Dynactin p62 has a punctate cytoplasmic distribution as well as centrosomal distribution typical of dynactin . In addition, Dynactin p62 is distributed in the nucleus at very high expression levels . Due to the structural composition of dynactin, the p62 subunit is implicated in Arp1 pointed-end binding and in linking dynein and dynactin to the cortical cytoskeleton.