E-AB-14925
DAB2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-14925
- Additional Names:
- DAB 2,DAB2,Dab,Differentially expressed in ovarian cancer 2,Differentially expressed protein 2,Disabled (Drosophila) homolog 2 (mitogen responsive phosphoprotein),Disabled homolog,Disabled homolog 2,homolog 2 (Drosophila),mitogen-responsive phosphoprotein
- Application:
- IHC, WB
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human DAB2
- Uniprot:
- P98082
- Synonyms:
- adaptor molecule disabled-2;Dab, mitogen-responsive phosphoprotein, homolog 2;DAB2, clathrin adaptor protein;differentially expressed in ovarian carcinoma 2;differentially-expressed protein 2;disabled homolog 2;disabled homolog 2, mitogen-responsive phosphoprotein;DOC-2;DOC2
- Extra Details:
- This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Shipping Conditions:
- Blue Ice