E-AB-14722
ELP2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-14722
- Additional Names:
- AU023723,ELP2,Elongation protein 2 homolog (S. cerevisiae),Elongator acetyltransferase complex subunit 2,Elongator complex protein 2,Epl2,FLJ10879,SHINC 2,SHINC-2,SHINC2,elongator protein 2,signal transducer and activator of transcription 3 interacti
- Application:
- IHC
- Concentration:
- 0.4 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human ELP2
- Uniprot:
- Q6IA86
- Synonyms:
- elongation protein 2 homolog;elongator complex protein 2;elongator protein 2;MRT58;SHINC-2;signal transducer and activator of transcription 3 interacting protein 1;STAT3-interacting protein 1;STATIP1;StIP
- Extra Details:
- One member of the STAT family, Stat3, participates in a wide range of biological processes including nephrogenesis, gliogenesis, hepatogenesis, T cell proliferation, inflammation and oncogenesis.Many of these responses are triggered by the IL-6 family of cytokines, which transduce their vital signals through a common gp130 receptor chain .A novel Stat3-Interacting Protein, StIP1, contains 12 WD40 repeats, which mediate protein-protein interactions .StIP1 exhibits an affinity for members of the JNK family and may play a specific role in regulating Stat3 activation.Overexpression of StIP1 blocks Stat3 activation, nuclear translocation and Stat3-dependent induction of a reporter gene, suggesting that StIP1 regulates the ligand-dependent activation of Stat3, probably by serving as a scaffold protein that promotes the interaction between JNK and the Stat3 substrate.
- Shipping Conditions:
- Blue Ice