E-AB-14690
DOK4 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-14690
- Additional Names:
- Downstream of tyrosine kinase 4,FLJ10488,IRS5,docking protein 4,insulin receptor substrate 5
- Application:
- IHC
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human DOK4
- Uniprot:
- Q8TEW6
- Synonyms:
- docking protein 4;downstream of tyrosine kinase 4;insulin receptor substrate 5;IRS-5;IRS5
- Extra Details:
- Docking protein 4 is a protein that in humans is encoded by the DOK4 gene.Dok-4 is a 326 amino acid protein that contains one PH domain and one IRS-type PTB domain and belongs to the Dok family of interacting proteins.Expressed in a variety of tissues with highest expression in liver, heart, kidney and skeletal muscle, Dok-4 plays an important role in Ret-mediated neurite outgrowth and may link Ret with downstream effectors during neuronal differentiation.Additionally, Dok-4 is thought to play a positive role in the activation of MAPK pathways and may participate in T-cell induced immune system regulation.Overexpression of Dok-4 is associated with clear cell renal cell carcinoma, suggesting a role for Dok-4 in tumorigenesis.
- Shipping Conditions:
- Blue Ice