E-AB-14113
CALR Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-14113
- Additional Names:
- Autoantigen RO,CALR,CALR protein,CRP55,CRT,CRTC,Calregulin,Calreticulin,ERp60,Endoplasmic reticulum resident protein 60,Epididymis secretory sperm binding protein Li 99n,FLJ26680,HACBP,HEL S 99n,RO,Sicca syndrome antigen A (autoantigen Ro,cC1qR,grp60
- Application:
- IHC, WB
- Concentration:
- 0.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human CALR
- Uniprot:
- P27797
- Synonyms:
- calregulin;calreticulin;cC1qR;CRP55;CRT;endoplasmic reticulum resident protein 60;epididymis secretory sperm binding protein Li 99n;ERp60;grp60;HACBP;HEL-S-99n;RO;Sicca syndrome antigen A (autoantigen Ro; calreticulin);SSA
- Extra Details:
- Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element.
- Shipping Conditions:
- Blue Ice