MKP-2 Polyclonal Antibody

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£106.20

Was £118.00

SKU:: E-AB-14071
Additional Names:: DUS4,DUSP 4,Dual specificity phosphatase 4,Dual specificity protein phosphatase 4,Dual specificity protein phosphatase hVH2,Dusp4,HVH 2,HVH2,MAP kinase phosphatase 2,Mitogen activated protein kinase phosphatase 2,Mitogen-activated protein kinase phosphata
Application:: IHC, WB
Concentration:: 0.5 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Recombinant protein of human DUSP4
Uniprot:: Q13115
Synonyms:: dual specificity protein phosphatase 4;dual specificity protein phosphatase hVH2;HVH2;MAP kinase phosphatase 2;mitogen-activated protein kinase phosphatase 2;MKP-2;MKP2;serine/threonine specific protein phosphatase;TYP;VH1 homologous phosphatase 2
Extra Details:: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

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