E-AB-14015
COX11 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-14015
- Additional Names:
- COX11P
- Application:
- IHC, WB
- Concentration:
- 0.5 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human COX11
- Uniprot:
- Q9Y6N1
- Synonyms:
- COX11 homolog, cytochrome c oxidase assembly protein;COX11, cytochrome c oxidase copper chaperone;COX11P;cytochrome c oxidase assembly protein COX11, mitochondrial;cytochrome c oxidase subunit 11
- Extra Details:
- Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes.The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex.This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies.However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of COX.This human protein is predicted to contain a transmembrane domain localized in the mitochondrial inner membrane.Multiple transcript variants encoding different isoforms have been found for this gene.A related pseudogene has been found on chromosome 6.
- Shipping Conditions:
- Blue Ice