E-AB-13841
COX10 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-13841
- Additional Names:
- 2410004F01Rik,AU042636,COX10,Cytochrome c oxidase assembly protein,Cytochrome c oxidase subunit X,Heme A farnesyltransferase,Heme O synthase,OTTMUSP00000006085,Protoheme IX farnesyltransferase,mitochond,mitochondrial
- Application:
- IHC
- Concentration:
- 0.4 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human COX10
- Uniprot:
- Q12887
- Synonyms:
- COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase;COX10, heme A:farnesyltransferase cytochrome c oxidase assembly factor;cytochrome c oxidase assembly homolog 10;cytochrome c oxidase assembly protein;cytochrome c oxidase subunit X;heme A: farnesyltransferase;heme O synthase;MC4DN3;protoheme IX farnesyltransferase, mitochondrial
- Extra Details:
- Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes heme A:farnesyltransferase, which is not a structural subunit but required for the expression of functional COX and functions in the maturation of the heme A prosthetic group of COX. This protein is predicted to contain 7-9 transmembrane domains localized in the mitochondrial inner membrane. A gene mutation, which results in the substitution of a lysine for an asparagine (N204K), is identified to be responsible for cytochrome c oxidase deficiency. In addition, this gene is disrupted in patients with CMT1A (Charcot-Marie-Tooth type 1A) duplication and with HNPP (hereditary neuropathy with liability to pressure palsies) deletion.
- Shipping Conditions:
- Blue Ice