E-AB-13556
HIF1AN Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-13556
- Additional Names:
- DKFZp762F1811,FIH 1,FIH-1,FIH1,FLJ20615,FLJ22027 ,Factor inhibiting HIF-1,Factor inhibiting HIF1,HIF1AN,HIF1N,Hyp,Hypoxia inducible factor 1 alpha inhibitor,Hypoxia inducible factor 1 alpha subunit inhibitor,Hypoxia inducible factor asparagine hydroxylase
- Application:
- IHC, WB
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human HIF1AN
- Uniprot:
- Q9NWT6
- Synonyms:
- factor inhibiting HIF-1;factor inhibiting HIF1;FIH-1;FIH1;hypoxia inducible factor 1 alpha subunit inhibitor;hypoxia-inducible factor 1-alpha inhibitor;hypoxia-inducible factor asparagine hydroxylase;peptide-aspartate beta-dioxygenase
- Extra Details:
- Factor inhibiting HIF-1 (FIH-1) exists as a homodimer and binds to HIF-1alpha.Specifically, FIH-1 operates as an asparaginyl hydroxylase.It catalyzes the hydroxylation of the beta-carbon of Asparagine residue 803 within the carboxy terminal transactivation domain of HIF-1alpha.This hydroxylation event blocks the association of HIF-1alpha with co-activators.FIH-1 also binds to von Hippel-Lindau (VHL) tumor suppressor protein, which represses transcriptional ac-tivity of HIF-1alpha.In transiently transfected human osteosarcoma cells, FIH-1 localizes to the cytoplasm.
- Shipping Conditions:
- Blue Ice