E-AB-13421
CAB39 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-13421
- Additional Names:
- CAB39,CGI 66,CGI-66,CGI66,Cab39,Calcium binding protein 39,Calcium-binding protein 39,MO25,MO25 alpha,Mouse protein 25 alpha,Protein Mo25
- Application:
- IHC, WB
- Concentration:
- 1.7 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human CAB39
- Uniprot:
- Q9Y376
- Synonyms:
- calcium-binding protein 39;CGI-66;MO25;MO25alpha;Protein Mo25
- Extra Details:
- Peutz-Jeghers Syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules of the lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. The serine/threonine kinase LKB1 (also designated STK11) has been identified as the gene mutated in PJS. LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the calcium binding protein 39 (MO25 alpha). STRAD and MO25 determine the subcellular localization of LKB1 by initiating its translocation from the nucleus to the cytoplasm, thus regulating the tumor suppressor activity of LKB1. The LKB1/STRAD/MO25 complex acts as an AMP-activated protein kinase kinase (AMPKK).
- Shipping Conditions:
- Blue Ice