E-AB-12870
SLC22A17 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-12870
- Additional Names:
- 24p3 receptor,24p3R,BOCT,BOIT,Brain type organic cation transporter,Brain-type organic cation transporter,Lipocalin-2 receptor,NGAL receptor,Neutrophil gelatinase associated lipocalin receptor,Neutrophil gelatinase-associated lipocalin receptor,Ngal,hBOIT
- Application:
- IHC
- Concentration:
- 0.3 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human SLC22A17
- Uniprot:
- Q8WUG5
- Synonyms:
- 24p3 receptor;24p3R;BOCT;BOIT;brain-type organic cation transporter;hBOIT;lipocalin-2 receptor;neutrophil gelatinase-associated lipocalin receptor;NGAL receptor;NGALR;NGALR2;NGALR3;potent brain type organic ion transporter;solute carrier family 22 (organic cation transporter), member 17;solute carrier family 22 member 17
- Extra Details:
- Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis.
- Shipping Conditions:
- Blue Ice