E-AB-12802
MDC1 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-12802
- Additional Names:
- Homologue to Drosophila photoreceptor protein calphotin,MDC 1,MDC1,Mdc1,Mediation of DNA damage checkpoint 1,Mediator of DNA damage checkpoint 1,Mediator of DNA damage checkpoint protein 1,NFBD 1,NFBD1,Nuclear Factor wit,Nuclear factor with BRCT domains 1
- Application:
- IHC
- Concentration:
- 1.2 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human MDC1
- Uniprot:
- Q14676
- Synonyms:
- homologue to Drosophila photoreceptor protein calphotin;mediator of DNA damage checkpoint protein 1;NFBD1;nuclear factor with BRCT domains 1
- Extra Details:
- The protein encoded by this gene contains an N-terminal forkhead domain, two BRCA1 C-terminal (BRCT) motifs and a central domain with 13 repetitions of an approximately 41-amino acid sequence. The encoded protein is required to activate the intra-S phase and G2/M phase cell cycle checkpoints in response to DNA damage. This nuclear protein interacts with phosphorylated histone H2AX near sites of DNA double-strand breaks through its BRCT motifs, and facilitates recruitment of the ATM kinase and meiotic recombination 11 protein complex to DNA damage foci.
- Shipping Conditions:
- Blue Ice