E-AB-12757
SMG8 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-12757
- Additional Names:
- ABC 2,ABC2,Amplified in breast cancer gene 2 protein,Chromosome 17 open reading,FLJ10587,Protein smg 8 homolog,SMG8,SMG8 protein,chromosome 17 open reading frame 71,protein SMG8
- Application:
- IHC
- Concentration:
- 0.3 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human SMG8
- Uniprot:
- Q8ND04
- Synonyms:
- ALKUS;amplified in breast cancer gene 2 protein;C17orf71;protein smg-8 homolog;protein SMG8;smg-8 homolog, nonsense mediated mRNA decay factor
- Extra Details:
- Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG9 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required to mediate the recruitment of SMG1 to the ribosome:SURF complex and to suppress SMG1 kinase activity until the ribosome:SURF complex locates the exon junction complex (EJC). Acts as a regulator of kinase activity.
- Shipping Conditions:
- Blue Ice