PTTG1 Polyclonal Antibody

Size

£106.20

Was £118.00

SKU:: E-AB-12630
Additional Names:: EAP1,HPTTG,PTTG,TUTR1
Application:: IHC
Concentration:: 0.3 mg/ml
Purification:: Affinity Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
Immunogen:: Synthetic peptide of human PTTG1
Uniprot:: O95997
Synonyms:: EAP1;Esp1-associated protein;ESP1-associated protein 1;HPTTG;pituitary tumor-transforming 1;pituitary tumor-transforming gene 1 protein;PTTG;securin;tumor-transforming protein 1;TUTR1
Extra Details:: The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.