E-AB-12444
GRPR Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-12444
- Additional Names:
- BB2,Bombesin BB2 receptor,GRP R,GRP preferring bombesin receptor,GRP-R,GRP-preferring bombesin receptor,GRPR,Gastrin Releasing Peptide Receptor,Gastrin-releasing peptide receptor,Grp/bombesin receptor,Grpr,bombesin receptor 2
- Application:
- IHC, WB
- Concentration:
- 1.1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human GRPR
- Uniprot:
- P30550
- Synonyms:
- BB2;BB2R;bombesin receptor 2;BRS2;gastrin-releasing peptide receptor;GRP-preferring bombesin receptor;GRP-R
- Extra Details:
- Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.
- Shipping Conditions:
- Blue Ice