E-AB-12373
DSP Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-12373
- Additional Names:
- 250/210 kDa paraneoplastic pemphigus antigen,DCWHKTA,DESP,DP,DP I,DP II,DPI,DPII,DSP,Desmoplakin,Desmoplakin (DPI DPII),Desmoplakin I,Desmoplakin II,KPPS2,PPKS 2,PPKS2
- Application:
- IHC
- Concentration:
- 0.5 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Synthetic peptide of human DSP
- Uniprot:
- P15924
- Synonyms:
- 250/210 kDa paraneoplastic pemphigus antigen;DCWHKTA;desmoplakin;DP
- Extra Details:
- Desmosomes are intercellular junctions that tightly link adjacent cells. Desmoplakin is an obligate component of functional desmosomes that anchors intermediate filaments to desmosomal plaques. The N-terminus of desmoplakin is required for localization to the desmosome and interacts with the N-terminal region of plakophilin 1 and plakoglobin. The C-terminus of desmoplakin binds with intermediate filaments. In the mid-region of desmoplakin, a coiled-coiled rod domain is responsible for homodimerization. Mutations in this gene are the cause of several cardiomyopathies and keratodermas as well as the autoimmune disease paraneoplastic pemphigus.
- Shipping Conditions:
- Blue Ice