E-AB-11188
KCNJ11 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-11188
- Additional Names:
- ATP sensitive inward rectifier potassium channel 11,BIR,Beta cell inward rectifier subunit,HHF 2,HHF2,IKATP,IRK 11,IRK11,Inward rectifier K(+) channel Kir6.2,Inwardly rectifying potassium channel KIR6.2,KCNJ11,Kir 6.2,Kir6.2,MGC133230,PHHI,Potassium chann
- Application:
- IHC
- Concentration:
- 0.6 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human KCNJ11
- Uniprot:
- Q14654
- Synonyms:
- ATP-sensitive inward rectifier potassium channel 11;beta-cell inward rectifier subunit;BIR;HHF2;IKATP;inward rectifier K(+) channel Kir6.2;inwardly rectifing potassium channel subfamily J member 11;inwardly rectifying potassium channel KIR6.2;inwardly-rectifying potassium channel subfamily J member 11;KIR6.2;MODY13;PHHI;PNDM2;potassium channel inwardly rectifing subfamily J member 11;potassium channel, inwardly rectifying subfamily J member 11;potassium voltage-gated channel subfamily J member 11;TNDM3
- Extra Details:
- Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
- Shipping Conditions:
- Blue Ice