E-AB-11148
DDIT4 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-11148
- Additional Names:
- DDIT4,DNA damage inducible transcript 4,DNA damage inducible transcript 4 protein,DNA damage-inducible transcript 4 protein,Dig2,FLJ20500,HIF 1 responsive RTP801,HIF 1 responsive protein RTP801,HIF-1 responsive protein RTP801,Protein regulated in de
- Application:
- IHC
- Concentration:
- 0.8 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human DDIT4
- Uniprot:
- Q9NX09
- Synonyms:
- Dig2;DNA damage-inducible transcript 4 protein;HIF-1 responsive protein RTP801;protein regulated in development and DNA damage response 1;REDD-1;REDD1
- Extra Details:
- REDD-1, also designated DNA-damage-inducible transcript 4, dig2 or RTP801, is thought to function in the regulation of reactive oxygen species (ROS). REDD-1 expression has also been linked to apoptosis, Ab toxicity and the pathogenesis of ischemic diseases. As an HIF-1-responsive gene, REDD-1 exhibits strong hypoxia-dependent upregulation in ischemic cells of neuronal origin. In response to stress due to DNA damage and glucocorticoid treatment, REDD-1 is upregulated at the transcriptional level. REDD-1 negatively regulates the mammalian target of Rapamycin (mTOR), a serine/threonine kinase often referred to as FRAP. It is crucial in the coupling of extra- and intracellular cues to FRAP regulation. The absence of REDD-1 is associated with the development of retinopathy, a major cause of blindness.
- Shipping Conditions:
- Blue Ice