E-AB-11008
BABAM2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-11008
- Additional Names:
- 6030405P19Rik,AI429776,B830038C02Rik,BRCA1 A complex subunit BRE,BRCA1-A complex subunit BRE,BRCA1/BR,Brain and reproductive organ expressed (TNFRSF1A modulator),Brain and reproductive organ-expressed protein,brain and reproductive organ expressed protein
- Application:
- IHC, WB
- Concentration:
- 0.5 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human BRE
- Uniprot:
- Q9NXR7
- Synonyms:
- brain and reproductive organ-expressed (TNFRSF1A modulator);brain and reproductive organ-expressed protein;BRCA1-A complex subunit BRE;BRCA1/BRCA2-containing complex subunit 45;BRCA1/BRCA2-containing complex, subunit 4;BRCC4;BRCC45;BRE;BRISC and BRCA1-A complex member 2
- Extra Details:
- Brain and reproductive organ-expressed protein (BRE) is a 415 amino acid protein which binds to the intracellular juxtamembrane domain of the death receptor, tumor necrosis factor receptor 1 (TNF-R1). BRE also binds to the death receptor, FAS. BRE downregulates TNFa-induced activation of NFkB and may play a role in homeostasis or cellular differentiation in cells of epithelial, neural and germ line origins. It inhibits components of the death-inducing signaling complexes that are necessary for activation of the mitochondria, thereby mediating apoptosis. BRE is strongly expressed in the adrenal cortex, medulla, testis and pancreas, and is weakly expressed in the thymus, thyroid, stomach and small intestine.
- Shipping Conditions:
- Blue Ice