E-AB-10878
USP2 Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-10878
- Additional Names:
- 41 kDa ubiquitin specific protease,41 kDa ubiquitin-specific protease,Deubiquitinating enzyme 2,Ubiquit,Ubiquitin carboxyl terminal hydrolase 2,Ubiquitin carboxyl-terminal hydrolase 2,Ubiquitin specific processing protease 2,ubiquitin specific peptidase 2
- Application:
- IHC
- Concentration:
- 0.3 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human USP2
- Uniprot:
- O75604
- Synonyms:
- 41 kDa ubiquitin-specific protease;deubiquitinating enzyme 2;ubiquitin carboxyl-terminal hydrolase 2;ubiquitin specific protease 12;ubiquitin specific protease 9;ubiquitin thioesterase 2;ubiquitin-specific-processing protease 2;UBP41;USP9
- Extra Details:
- This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
- Shipping Conditions:
- Blue Ice