E-AB-10671
pVHL Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-10671
- Additional Names:
- E3 ubiquitin pro,Elongin binding protein,G7 protein,HRCA 1,HRCA1,Protein G7,RCA 1,RCA1,VHL,VHL 1,VHL1,VHLH,Von Hippel Lindau disease tumor suppressor,Von Hippel Lindau tumor suppressor,pVHL,von Hippel Lindau syndrome,von Hippel Lindau tumor suppressor
- Application:
- IHC
- Concentration:
- 0.4 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human VHL
- Uniprot:
- P40337
- Synonyms:
- elongin binding protein;HRCA1;protein G7;pVHL;RCA1;VHL1;von Hippel-Lindau disease tumor suppressor;von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
- Extra Details:
- Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
- Shipping Conditions:
- Blue Ice