E-AB-10510
CDKN2AIP Polyclonal Antibody
Size
£106.20
Was £118.00
- SKU:
- E-AB-10510
- Additional Names:
- CARF,CDKN2A interacting protein,CDKN2A-interacting protein,Calcium response factor,Cdkn2aip,Collaborator of ARF,FLJ20036,collaborates/cooperates with ARF (alternate reading frame) protein
- Application:
- IHC
- Concentration:
- 0.3 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant protein of human CDKN2AIP
- Uniprot:
- Q9NXV6
- Synonyms:
- CARF;CDKN2A-interacting protein;collaborates/cooperates with ARF (alternate reading frame) protein;collaborator of ARF
- Extra Details:
- CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.
- Shipping Conditions:
- Blue Ice