D-AB-10417L
DNase-I Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- D-AB-10417L
- Additional Names:
- DRNI,DNASE1,DNL1,DNase I,Deoxyribonuclease I,Deoxyribonuclease-1,Dornase alfa
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Human DNase-I protein expressed by Mammalian
- Uniprot:
- P24855
- Synonyms:
- deoxyribonuclease I;deoxyribonuclease-1;DNase I, lysosomal;DNL1;Dornase alfa;DRNI;human urine deoxyribonuclease I
- Extra Details:
- DNase1,also known as deoxyribonuclease I and DNL1,is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide,yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3',on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations in DNase1 gene have been associated with systemic lupus erythematosus (SLE),an autoimmune disease. DNase1 is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.
- Shipping Conditions:
- Blue Ice