D-AB-10373L
MMP-1 Polyclonal Antibody
Size
£120.60
Was £134.00
- SKU:
- D-AB-10373L
- Additional Names:
- CLGN, EC 3.4.24, EC 3.4.24.7, Fibroblast collagenase, MMP, MMP1, Matrix metalloproteinase-1, interstitial collagenase, matrix metallopeptidase 1 (interstitial collagenase), matrix metalloproteinase 1 (interstitial collagenase),CLGmatrix metalloprotease 1
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Affinity Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS with 0.05% Proclin300, 1% protective protein and 50% glycerol, pH7.4
- Immunogen:
- Recombinant Mouse MMP-1 protein expressed by E.coli
- Uniprot:
- Q9EPL5
- Synonyms:
- collagenase-like A;interstitial collagenase A;matrix metalloproteinase 1a (interstitial collagenase);Matrix metalloproteinase-1a;Mco;Mcol-A;Mcola;MMP-1a
- Extra Details:
- Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-1 (interstitial collagenase), can degrade a broad range of substrates including types I, II, III, VII, VIII, and X collagens as well as casein, gelatin,alpha -1 antitrypsin, myelin basic protein, L-Selectin, pro-TNF, IL-1 beta, IGF-BP3, IGF-BP5, pro MMP-2 and pro MMP-9. A significant role of MMP-1 is the degradation of fibrillar collagens in extracellular matrix remodeling, characterized by the cleavage of the interstitial collagen triple helix into ¾, ¼ fragments. However, as the list of substrates above illustrates, the role of MMP-1 is more diverse than originally envisaged, and may involve enzyme cascades, cytokine regulation and cell surface molecule modulation. MMP-1 is expressed by fibroblasts, keratinocytes, endothelial cells, monocytes and macrophages. Structurally, MMP-1 may be divided into several distinct domains, a pro-domain which is cleaved upon activation, a catalytic domain containing the zinc binding site, a short hinge region and a carboxyl terminal (hemopexin-like) domain.
- Shipping Conditions:
- Blue Ice