CQM014
CellaQuant[TM] Mouse IL-5 (Interleukin 5) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- CQM014
- Additional Names:
- B-cell differentiation factor I,BCGFII,EDF,Eo-CSF,Eosinophil differentiation factor,IL5,IL-5,IL-5T-cell replacing factor,interleukin-5,TRF,TRFB cell differentiation factor I
- Application:
- ELISA
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P04401
- Synonyms:
- B-cell growth factor II;BCGF-II;cytotoxic T-lymphocyte inducer;eosinophil differentiation factor;Il;Il-5;interleukin-5;T-cell replacing factor;TRF
- Extra Details:
- Interleukin-5 (IL-5) is a homodimeric cytokine, where two identical 126-amino-acid monomers are linked by a disulfide bond. It is primarily secreted by activated Th2 cells, with additional sources including eosinophils, mast cells, iNKT cells, and NK cells.IL-5 is the principal regulator of eosinophils, driving their differentiation, survival, activation, and chemotaxis. It also activates basophils. Beyond granulocytes, IL-5 acts on B cells to promote immunoglobulin production, growth, and differentiation, linking it to humoral immunity. Its biological effects are mediated by a cell surface receptor complex composed of a unique IL-5RA Alpha chain and the common beta chain (B Betac/CD131). Receptor engagement activates JAK2 and other kinases, triggering downstream JAK-STAT5 and RAS-MAPK signaling pathways. Bioavailability is naturally regulated by soluble IL-5RA Alpha, which acts as a decoy receptor. Thus, IL-5 is a central cytokine in type 2 immunity, allergic inflammation, and antibody responses, making it a key therapeutic target for eosinophil-driven diseases.
- Shipping Conditions:
- Blue Ice