CellaQuant[TM] Mouse IL-17A (Interleukin 17A) ELISA Kit

Size

£128.70

Was £143.00

SKU:: CQM013
Additional Names:: CTLA8,CTLA-8,CTLA8cytotoxic T-lymphocyte-associated serine esterase 8,Cytotoxic T-lymphocyte-associated antigen 8,IL17,IL-17,IL17A,IL-17A,IL-17Acytotoxic T-lymphocyte-associated protein 8,IL-17CTLA-8,IL17interleukin-17A,interleukin 17A
Application:: ELISA
Physical State:: Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
Species Reactivity:: Mouse
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: Q62386
Synonyms:: Ctl;Ctla;Ctla-8;Ctla8;cytotoxic T-lymphocyte-associated antigen 8;Il;IL-;IL-17;IL-17A;Il17;interleukin-17A
Extra Details:: Interleukin-17A (IL-17A) is a 15-20 kDa glycosylated, pro-inflammatory cytokine and a central member of the IL-17 family (A-F). It is primarily secreted by T helper 17 (Th17) cells but also by innate immune cells like G GammaD Delta T cells, iNKT cells, and group 3 innate lymphoid cells (ILC3s). IL-17A signals through a heterodimeric receptor complex of IL-17RA and IL-17RC, activating NF-K KappaB and MAPK pathways via the adaptor TRAF3IP2. This induces the expression of chemokines (e.g., CXCL1, CXCL5), antimicrobial peptides (e.g., defensins), and matrix metalloproteinases. Its primary function is to bridge adaptive and innate immunity by robustly recruiting and activating neutrophils to clear extracellular bacterial and fungal infections. It also maintains epithelial barrier integrity and promotes mucosal host defense. Furthermore, IL-17A regulates B cell responses in germinal centers and participates in antiviral immunity. IL-17A can form homodimers or heterodimers with the closely related IL-17F (sharing 50% homology). While both homodimers and the heterodimer are bioactive, IL-17A is the most potent driver of neutrophil migration. Beyond host defense, IL-17A has a dual role in pathology. It is a key driver of chronic inflammation and autoimmunity (e.g., rheumatoid arthritis, psoriasis) and can promote tumorigenesis. Conversely, it can exhibit protective functions in colitis and exert anti-tumor effects in certain contexts, making it a complex and critical therapeutic target.

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