CQM009
CellaQuant[TM] Mouse IL-1A Alpha (Interleukin 1 Alpha) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- CQM009
- Additional Names:
- IL1A,IL-1A,IL1,IL1-ALPHA,IL1F1
- Application:
- ELISA
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Reactivities:
- Mouse
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P01582
- Synonyms:
- Il;IL-1 alpha;Il-1a;interleukin-1 alpha
- Extra Details:
- Interleukin-1 (IL-1) comprises two proteins, IL-1A Alpha and IL-1B Beta, encoded by separate genes but functioning similarly. Both are synthesized as 31 kDa precursors lacking a signal peptide and processed to ~17 kDa mature forms. IL-1A Alpha is often active as a precursor and retained intracellularly or membrane-bound, whereas IL-1B Beta requires caspase-1 cleavage for activation and release.Produced by monocytes, macrophages, fibroblasts, endothelial cells, and neural cells, IL-1 signals mainly through IL-1 receptor type I (IL-1RI). IL-1 receptor type II (IL-1RII) acts as a decoy, inhibiting signaling by sequestering IL-1.A key mediator of innate immunity and inflammation, IL-1 induces fever, immune cell activation, cytokine release, and acute-phase responses. It also influences hematopoiesis, bone metabolism, and contributes to autoimmune, vascular, and neurodegenerative diseases. Its activity is regulated transcriptionally, post-translationally, via receptor balance, and by antagonists like IL-1Ra.
- Shipping Conditions:
- Blue Ice