CQM006
CellaQuant[TM] Mouse IL-2 (Interleukin 2) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- CQM006
- Additional Names:
- Interleukin-2,IL2,TCGF,T-cell growth factor,Il-2
- Application:
- ELISA
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Species Reactivity:
- Mouse
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P04351
- Synonyms:
- IL;Il-2;interleukin-2;T-cell growth factor;TCGF
- Extra Details:
- Interleukin-2(IL-2), or T-cell growth factor(TCGF), is a 15-18 kDa glycosylated cytokine in the common gamma chain(G Gammac)family, with a short half-life under 30 minutes. It is produced by activated CD4+and CD8+T cells, G GammaD DeltaT cells, microglia, and hematopoietic stem cells.The IL-2 receptor consists of CD25(IL-2RA Alpha), IL-2RB Beta, and G Gammac subunits. IL-2 binding to CD25 recruits IL-2RB Beta and G Gammac to form a signaling complex. IL-2RB Beta is also used by IL-15, and G Gammac is shared by multiple cytokines including IL-4, IL-7, and IL-15.IL-2 drives T cell activation and expansion in vitro. In vivo, it is essential for regulatory T cell(Treg)development and function, preventing autoimmunity, but can also promote inflammatory responses via Th2 cytokines and trafficking gene regulation. In CD8+T cells, IL-2 enhances effector differentiation and memory formation.
- Shipping Conditions:
- Blue Ice