CellaQuant[TM] Mouse IL-10 (Interleukin 10) ELISA Kit

Size

£128.70

Was £143.00

SKU:: CQM004
Additional Names:: CSIF,Cytokine synthesis inhibitory factor,GVHDS,IL10,IL-10,IL10A,interleukin 10,interleukin-10,TGIF
Application:: ELISA
Physical State:: Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
Species Reactivity:: Mouse
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Reactivities:: Mouse
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P18893
Synonyms:: CSIF;cytokine synthesis inhibitory factor;If2a;IL-;Il-10;interferon 2a;interleukin-10
Extra Details:: Interleukin-10 (IL-10), initially termed Cytokine Synthesis Inhibitory Factor (CSIF), is a pivotal immunoregulatory cytokine with profound anti-inflammatory functions. It is primarily produced by activated macrophages, but also by various lymphocytes and stromal cells.IL-10 signals through a heterotetrameric receptor complex composed of two IL-10RA Alpha and two IL-10RB Beta subunits. Binding triggers JAK1-mediated phosphorylation of STAT3, which translocates to the nucleus to drive the expression of anti-inflammatory genes.Its primary mechanism involves targeting antigen-presenting cells (APCs), such as macrophages and monocytes. IL-10 potently suppresses their production of pro-inflammatory cytokines (e.g., TNF-A Alpha, IL-6, IL-1) and downregulates MHC class II and co-stimulatory molecules, thereby inhibiting T cell activation. This curbs excessive inflammation and limits tissue damage.However, IL-10 exhibits context-dependent duality. While it supports regulatory T cell function and is generally immunosuppressive, it can also stimulate immune responses in specific settings like the tumor microenvironment, promoting CD8+ T cell activity. Consequently, dysregulated IL-10 is implicated in pathologies ranging from autoimmune diseases and persistent infections to cancer. Thus, IL-10 is a master regulator essential for immune homeostasis, balancing protective immunity with inflammatory suppression.

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