CellaQuant[TM] Human IL-33 (Interleukin 33) ELISA Kit

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£128.70

Was £143.00

SKU:: CQH020
Additional Names:: C9orf26,DVS27,IL1F11,IL-1F11,IL33,IL-33,interleukin 33,Interleukin-1 family member 11,interleukin-33,NFHEV,NF-HEV,NF-HEVNFEHEV,Nuclear factor from high endothelial venules
Application:: ELISA
Physical State:: Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Reactivities:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: O95760
Synonyms:: C9orf26;DVS27;DVS27-related protein;IL1F11;interleukin-1 family member 11;interleukin-33;NF-HEV;NFEHEV;nuclear factor for high endothelial venules;nuclear factor from high endothelial venules
Extra Details:: Interleukin-33 (IL-33) is a dual-function protein belonging to the IL-1 cytokine family, discovered independently as DVS27 and nuclear factor from high endothelial venules (NF-HEV). It is constitutively expressed as a 30 kDa pro-form, notably in vascular smooth muscle, endothelial cells, and airway epithelia. In its full-length form, IL-33 localizes to the nucleus via a nuclear localization sequence, where it binds chromatin and can act as a transcriptional regulator, potentially repressing NF-K KappaB target genes in quiescent endothelium.Upon cellular stress or damage, full-length IL-33 is processed by inflammatory caspases (e.g., caspase-1) into a mature, bioactive cytokine. This mature form functions as a potent "alarmin," signaling through a receptor complex comprising ST2 (IL1RL1) and IL-1RAcP. This engagement activates canonical NF-K KappaB and MAPK pathways.IL-33 is a central driver of type 2 immunity. It promotes Th2 cell differentiation and the secretion of cytokines like IL-5 and IL-13, activates mast cells, eosinophils, and basophils, and enhances alternative (M2) macrophage polarization. Consequently, it plays key roles in allergic inflammation, helminth responses, and tissue repair. Its rapid release from damaged cells positions IL-33 as a critical sentinel at the interface of innate and adaptive immunity.

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