CQH019
CellaQuant[TM] Human IL-12 (Interleukin 12) ELISA Kit
Size
£120.60
Was £134.00
- SKU:
- CQH019
- Additional Names:
- Interleukin-12 subunit alpha,IL-12A,NKSF1,NK cell stimulatory factor chain 1
- Application:
- ELISA
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Species Reactivity:
- Human
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Reactivities:
- Human
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P29459
- Synonyms:
- CLMF;CLMF p35;cytotoxic lymphocyte maturation factor 1, p35;cytotoxic lymphocyte maturation factor 35 kDa subunit;IL-12 subunit p35;IL-12, subunit p35;IL-12A;IL35 subunit;interleukin 12, p35;interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35);interleukin-12 alpha chain;interleukin-12 subunit alpha;NF cell stimulatory factor chain 1;NFSK;NK cell stimulatory factor chain 1;NKSF1;P35
- Extra Details:
- IL-12 p70 is the biologically active heterodimer of interleukin-12 (IL-12), consisting of disulfide-linked IL-12A (p35) and IL-12B (p40) subunits with a molecular weight of approximately 70 kDa. It is primarily produced by professional antigen-presenting cells (APCs) following antigen stimulation, which distinguishes it from inactive p40 monomers or homodimers. Functionally, IL-12 p70 induces interferon-gamma (IFN-G Gamma) production, promotes the differentiation of naive T cells into T-helper 1 (Th1) cells, and enhances the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). It exerts its effects by binding to the IL12RB Beta1/B Beta2 heterodimeric receptor, which activates JAK-STAT4 signaling to regulate cytokine-responsive gene expression.IL-12 p70 shares the p40 subunit with IL-23 and the p35 subunit with IL-35. As a key link between innate and adaptive immunity, it plays a vital role in research on infectious diseases, autoimmune disorders, and cancer immunotherapy.
- Shipping Conditions:
- Blue Ice