CellaQuant[TM] Human IL-23 (Interleukin 23) ELISA Kit

Size

£128.70

Was £143.00

SKU:: CQH013
Additional Names:: IL23,IL-23,IL-23A,IL-23-A,IL-23p19,interleukin 23, alpha subunit p19,interleukin-23 subunit alpha,Interleukin-23 subunit p19,JKA3 induced upon T-cell activation
Application:: ELISA
Physical State:: Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
Species Reactivity:: Human
Storage Conditions:: 2-8[o]C
Supplier:: Elabscience
Reactivities:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P29460
Synonyms:: CLMF;CLMF p40;CLMF2;cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p40;IL-12B;IL-23;IL-23 subunit alpha;IL-23-A;IL-23A;IL-23p19;IL12, subunit p40;IL23P19;IMD28;IMD29;interleukin 12, p40;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin 23 p19 subunit;interleukin 23, alpha subunit p19;interleukin-12 beta chain;interleukin-12 subunit beta;interleukin-23 subunit alpha;interleukin-23 subunit p19;interleukin-six, G-CSF related factor;JKA3 induced upon T-cell activation;natural killer cell stimulatory factor, 40 kD subunit;NK cell stimulatory factor chain 2;NKSF;NKSF2;P19;SGRF
Extra Details:: Interleukin-23 (IL-23) is a heterodimeric cytokine pivotal in bridging innate and adaptive immunity. It is composed of two disulfide-linked subunits: a unique p19 subunit (IL-23A) and a p40 subunit (IL-12B) shared with IL-12. While p19 is expressed by various activated immune and endothelial cells, the concurrent expression of p40-primarily by activated macrophages and dendritic cells-is the critical limiting step for functional IL-23 production.IL-23 signals through a heterodimeric receptor complex consisting of IL-12RB Beta1 and the IL-23-specific IL-23R. This interaction activates the JAK2/STAT signaling cascade, leading to phosphorylation of STAT1, STAT3, STAT4, and STAT5.Functionally, IL-23 has distinct roles from IL-12. Its action is largely restricted to memory T cells, driving their proliferation and, crucially, their production of the potent pro-inflammatory cytokine IL-17. This IL-23/IL-17 axis is a central mediator of inflammatory and autoimmune pathogenesis. Additionally, IL-23 can enhance immunogenic antigen presentation by CD8+ dendritic cells. Thus, IL-23 is a key regulator of inflammatory responses, critically involved in host defense, autoimmune diseases, and tumor immunology.

Shipping Conditions:: Blue Ice