CQH011
CellaQuant[TM] Human IL-22 (Interleukin 22) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- CQH011
- Additional Names:
- L-10-related T-cell-derived inducible factor,IL22,IL-22,IL-D110,IL-TIF,ILTIFIL-10-related T-cell-derived-inducible factor,IL-TIFMGC79382,interleukin 22,interleukin-22
- Application:
- ELISA
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Species Reactivity:
- Human
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Reactivities:
- Human
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q9GZX6
- Synonyms:
- cytokine Zcyto18;IL-10-related T-cell-derived inducible factor;IL-10-related T-cell-derived-inducible factor;IL-21;IL-22;IL-D110;IL-TIF;ILTIF;interleukin-22;TIFa;TIFIL-23;zcyto18
- Extra Details:
- Interleukin-22 (IL-22), initially identified as an IL-9-inducible gene (IL-TIF), is a member of the IL-10 cytokine family. The human protein is produced as a 179-amino-acid precursor, cleaved to a 147-aa active form, sharing ~22% and ~79% sequence identity with human IL-10 and mouse IL-22, respectively. Its gene is located on chromosome 12q15. IL-22 signals through a heterodimeric cell surface receptor composed of IL-22R1 (CRF2-9) and IL-10R2 (CRF2-4), activating STAT1 and STAT3 pathways. Its activity is further modulated by a soluble inhibitor, IL-22 binding protein (IL-22BP). Primarily produced by immune cells like activated T cells and Th17 lymphocytes, IL-22 acts predominantly on non-immune epithelial and stromal cells. It plays a critical role in mucosal host defense, tissue repair, and the induction of acute-phase proteins. However, it also contributes to the pathogenesis of chronic inflammatory and autoimmune diseases, highlighting its dual role in regulating tissue homeostasis and inflammation.
- Shipping Conditions:
- Blue Ice