CQH006
CellaQuant[TM] Human KIM-1 (Kidney Injury Molecule 1) ELISA Kit
Size
£128.70
Was £143.00
- SKU:
- CQH006
- Additional Names:
- HAVCR1,HAVCR,HAVCR-1,KIM-1,KIM1,TIM,TIM-1,TIM1,TIMD-1,TIMD1
- Application:
- ELISA
- Physical State:
- Cell Culture Supernatant, Cell Lysate, Other Biological Fluid
- Species Reactivity:
- Human
- Storage Conditions:
- 2-8[o]C
- Supplier:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- Q96D42
- Synonyms:
- ACPA;AGP7;azurophil granule protein 7;C-ANCA;C-ANCA antigen;CANCA;CD365;HAVCR;HAVCR-1;hepatitis A virus cellular receptor 1;kidney injury molecule 1;KIM-1;KIM1;leukocyte proteinase 3;MBN;MBT;myeloblastin;neutrophil proteinase 4;NP-4;NP4;P29;PR-3;PR3;serine proteinase, neutrophil;T cell immunoglobin domain and mucin domain protein 1;T-cell immunoglobulin and mucin domain-containing protein 1;T-cell immunoglobulin mucin family member 1;T-cell immunoglobulin mucin receptor 1;T-cell membrane protein 1;TIM;TIM-1;TIM1;TIMD-1;TIMD1;wegener autoantigen;Wegener granulomatosis autoantigen
- Extra Details:
- TIM-1 (T-cell immunoglobulin and mucin domain protein 1, also known as KIM-1 and HAVCR) is a 70-80 kDa type I transmembrane glycoprotein belonging to the TIM immunoglobulin superfamily (1-4). This family regulates the balance between Th1 and Th2 immune responses. Structurally, TIM proteins contain an N-terminal immunoglobulin variable (IgV) domain, a glycosylated mucin domain, a transmembrane region, and a cytoplasmic tail.TIM proteins recognize phosphatidylserine exposed on apoptotic cells via a metal-ion-dependent binding pocket within the IgV domain. Notably, mouse TIM-2 lacks this pocket and does not bind phosphatidylserine. TIM-1 also interacts with P-selectin (CD62P) with higher affinity than with E- or L-selectin, mediating T-cell trafficking and costimulation. Studies using a contact hypersensitivity model indicate that TIM-1-P-selectin interaction facilitates the migration of activated T cells to inflamed skin.
- Shipping Conditions:
- Blue Ice