AN302107L
Recombinant Histone H2B (Ubiquityl Lys120) Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302107L
- Additional Names:
- HIST1H2BG,H2B.1A,H2B/a,H2BFA,H2BFL,HIST1H2BC,H2BFH,HIST1H2BE,H2BFG,HIST1H2BF,H2BFK,HIST1H2BI,H2BC4,H2BC6,H2BC7,H2BC8,H2BC10
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Ubiquitinated human histone H2B (Lys120) peptide
- Clone:
- A831
- Uniprot:
- P62807
- Synonyms:
- dJ221C16.3;dJ221C16.6;dJ221C16.8;H2B histone family, member A;H2B histone family, member B;H2B histone family, member G;H2B histone family, member H;H2B histone family, member K;H2B histone family, member L;H2B.1;H2B.1A;H2B.1B;H2B.h;H2B/a;H2B/b;H2B/g;H2B/h;H2B/k;H2B/l;H2BC10;H2BC4;H2BC6;H2BC7;H2BC8;H2BFA;H2BFB;H2BFG;H2BFH;H2BFK;H2BFL;HIRA-interacting protein 2;HIRIP2;HIST1H2BC;HIST1H2BD;HIST1H2BE;HIST1H2BF;HIST1H2BG;HIST1H2BI;histone 1, H2bc;histone 1, H2bd;histone 1, H2be;histone 1, H2bf;histone 1, H2bg;histone 1, H2bi;histone cluster 1 H2B family member c;histone cluster 1 H2B family member d;histone cluster 1 H2B family member e;histone cluster 1 H2B family member f;histone cluster 1 H2B family member g;histone cluster 1 H2B family member i;histone cluster 1, H2bc;histone cluster 1, H2bd;histone cluster 1, H2be;histone cluster 1, H2bf;histone cluster 1, H2bg;histone cluster 1, H2bi;Histone H2B type 1-C/E/F/G/I;histone H2B type 1-D;Histone H2B.1 A;histone H2B.1 B;Histone H2B.a;histone H2B.b;Histone H2B.g;Histone H2B.h;Histone H2B.k;Histone H2B.l
- Extra Details:
- Ubiquitin (Ub) is a highly conserved 76-amino acid protein that plays a critical role in regulating a wide range of cellular processes. Through a three-step process involving Ub-activating (E1), Ub-conjugating (E2), and Ub-ligating (E3) enzymes, ubiquitin covalently attaches to target proteins and marks them for proteasomal degradation, alters protein-protein interactions, modulates membrane protein trafficking, and controls the activity of many signal transduction pathways. Mono-ubiquitination of Histone H2B at Lys120 (H2BK120ub) serves signaling purposes and is reversible by ubiquitin-specific proteases (USPs). The enzymes responsible for H2BK120ub are Rad6 E2 proteins (HR6A and HR6B in human) and Bre1 E3 ligase (RNF20 and RNF40 in human). This modification triggers a "trans-histone" modification cascade, resulting in trimethylation of Lys4 and Lys79 in histone H3, which promotes gene activity.
- Shipping Conditions:
- Blue Ice