AN302103L
Recombinant Phospho-BTK (Tyr551) Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302103L
- Additional Names:
- IMD,AGMX,PSCTK,AGMX1,AT,ATK,BPK,IMD1,PSCTK1,XLA,BTK,Bruton tyrosine kinase,AGMX1,ATK,BPK,Bruton tyrosine kinase,IMD1,PSCTK1,XLA
- Application:
- Flow Cytometry
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab
- Clone:
- A827
- Uniprot:
- Q06187
- Synonyms:
- agammaglobulinaemia tyrosine kinase;Agammaglobulinemia tyrosine kinase;AGMX1;AT;ATK;B-cell progenitor kinase;BPK;Bruton agammaglobulinemia tyrosine kinase;Bruton tyrosine kinase;Bruton's tyrosine kinase;dominant-negative kinase-deficient Brutons tyrosine kinase;IGHD3;IMD1;PSCTK1;truncated Bruton agammaglobulinemia tyrosine kinase;tyrosine-protein kinase BTK;XLA
- Extra Details:
- Bruton's tyrosine kinase (Btk) is a member of the Btk/Tec family of cytoplasmic tyrosine kinases. Like other Btk family members, it contains apleckstrin homology (PH) domain and Src homology SH3 and SH2 domains. Btk plays an important role in B cell development. Activation ofB cells by various ligands is accompanied by Btk membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5-trisphosphate. The membrane-localized Btk is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 andTyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinases, leading to autophosphorylation at Tyr223 withinthe SH3 domain, which is necessary for full activation. The activation of Btk is negatively regulated by PKCB Beta through phosphorylation of Btkat Ser180, which results in reduced membrane recruitment, transphosphorylation, and subsequent activation. The PKC inhibitory signal islikely to be a key determinant of the B cell receptor signaling threshold to maintain optimal Btk activity.
- Shipping Conditions:
- Blue Ice