AN302086L
Recombinant Phospho-SIRT1(Ser47) Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302086L
- Additional Names:
- SIR,HST,SIRT,Hsir,homolog-like,SIR2 like protein,Regulatory protein SIR2 homolog,NAD-dependent deacetylase sirtuin,Sirtuin (silent mating type information regulation 2 homolog),SIR2L,Hsirt,75SirT,sirtuin,SIRT1,SIR2,SIR2L1,SIR2alpha,sirtuin 1,75SirT1,Hsir2,Hsirt1,HST2,S.cerevisiae,NAD-dependent deacetylase sirtuin-1,Regulatory protein SIR2 homolog 1,SIR2 like protein 1,homolog-like 1,SirtT1 75 kDa fragment,Sirtuin (silent mating type information regulation 2 homolog)
- Application:
- IHC, WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- phosphorylated human SIRT1(Ser47) peptide
- Clone:
- A810
- Uniprot:
- Q96EB6
- Synonyms:
- NAD-dependent protein deacetylase sirtuin-1;NAD-dependent protein deacylase sirtuin-1;regulatory protein SIR2 homolog 1;SIR2;SIR2-like protein 1;SIR2alpha;SIR2L1;sirtuin type 1
- Extra Details:
- SIRT1, the mammalian ortholog of Sir2, is a nuclear protein implicated in the regulation of many cellular processes, including apoptosis, cellular senescence, endocrine signaling, glucose homeostasis, aging, and longevity. Targets of SirT1 include acetylated p53, p300, Ku70, forkhead (FoxO) transcription factors, PPARG Gamma, and the PPARG Gamma coactivator-1A Alpha (PGC-1A Alpha) protein. Deacetylation of p53 and FoxO transcription factors represses apoptosis and increases cell survival. Deacetylation of PPARG Gamma and PGC-1A Alpha regulates the gluconeogenic/glycolytic pathways in the liver and fat mobilization in white adipocytes in response to fasting. SirT1 deacetylase activity is inhibited by nicotinamide and activated by resveratrol. In addition, SirT1 activity may be regulated by phosphorylation, as it is phosphorylated at Ser27 and Ser47 in vivo, however, the function of these phosphorylation sites has not yet been determined.
- Shipping Conditions:
- Blue Ice