AN302080L
Recombinant Phospho-YAP1 (Ser127) Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302080L
- Additional Names:
- COB,COB1,YAP,YAP2,YAP65,YKI,YAP1,65 kDa Yes associated protein,65 kDa Yes-associated protein,Basic protease inhibitor,BPTI,Pancreatic Trypsin Inhibitor,Trasylol,YAp 1,YAP 65,Yes associated protein 1,Yes associated protein 1 65kDa,Yes associated protein 2,yes associated protein beta,yes -associated protein delta,Yorkie homolog
- Application:
- Flow Cytometry, IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- phosphorylated human YAP1 (Ser1270) peptide
- Clone:
- A804
- Uniprot:
- P46937
- Synonyms:
- 65 kDa Yes-associated protein;COB1;protein yorkie homolog;transcriptional coactivator YAP1;YAP;YAP2;YAP65;Yes associated protein 1;yes-associated protein 2;yes-associated protein YAP65 homolog;YKI;yorkie homolog
- Extra Details:
- Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein. Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
- Shipping Conditions:
- Blue Ice