AN302076L
Recombinant Phospho-S6 Ribosomal Protein (Ser235, Ser236) Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302076L
- Additional Names:
- RPS,OK/SW-cl,RPS6,S6,OK/SW-cl.2
- Application:
- IHC, WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Phosphorylated human S6 ribosomal protein (Ser235/236) peptide
- Clone:
- A796
- Uniprot:
- P62753
- Synonyms:
- 40S ribosomal protein S6;phosphoprotein NP33;S6;small ribosomal subunit protein eS6
- Extra Details:
- Ribosomal Protein S6 (RPS6), a highly conserved component of the eukaryotic 40S small ribosomal subunit, functions as a critical regulatory nexus that translates extracellular and intracellular signals into the control of cell growth and proliferation. This activity is tightly governed by the PI3K/Akt/mTOR signaling cascade, a master regulatory pathway that integrates inputs from growth factors and nutrient availability. In response to mitogenic or anabolic stimuli that activate this pathway, the downstream effector kinase p70 S6K1 mediates the hierarchical phosphorylation of RPS6 on a cluster of serine residues located in its C-terminus, with the phosphorylation of the adjacent serines 235 and 236 representing a canonical hallmark of mTORC1 activation. This specific post-translational modification is mechanistically linked to the primary regulatory function of RPS6, which is to facilitate the selective and efficient translation of a specific cohort of messenger RNAs characterized by a 5' terminal oligo-pyrimidine tract (5' TOP).
- Shipping Conditions:
- Blue Ice