AN302066L
Recombinant NELF-B Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302066L
- Additional Names:
- KIAA,COBRA,NELFB,COBRA1,NELF-B,KIAA1182
- Application:
- Flow Cytometry, IHC, WB, IP
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Clone:
- A786
- Uniprot:
- Q8WX92
- Synonyms:
- COBRA1;cofactor of BRCA1;negative elongation factor B;negative elongation factor protein B;NELF-B
- Extra Details:
- NELF-B is an essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNApolymerase II. The NELF complex causes transcriptional pausing and is counteracted by the P-TEFb kinase complex. It may be able toinduce chromatin unfolding. NELF-B is a modulator of ligand dependent and independent expression of estrogen receptor-A Alpha target genes.NELF-B expression is reduced in metastatic and recurrent breast cancer, suggesting that low levels of NELF-B in breast cancers may serveas an indicator for poor prognosis.
- Shipping Conditions:
- Blue Ice