Recombinant EGR2 Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN302056L
Additional Names:: EGR,KROX,EGR2,AT591,CMT1D,CMT4E,KROX20,DKFZp686J1957,Drosophila,E3 SUMO-protein ligase EGR2,early growth response 2,Early growth response protein 2,EGR-2,FLJ14547,homolog (early growth response-2),KROX 20 Drosophila homolog,Krox 20 homolog Drosophila,KROX-20,Krox20 protein,Zinc finger protein Krox-20
Application:: WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human, Mouse, Rat
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Peptide. This information is proprietary to PTMab.
Clone:: A776
Uniprot:: P11161
Synonyms:: AT591;CHN1;CMT1D;CMT4E;E3 SUMO-protein ligase EGR2;E3 SUMO-protein transferase ERG2;early growth response protein 2;KROX-20, Drosophila, homolog (early growth response-2);KROX20;zinc finger protein Krox-20
Extra Details:: EGR2 is also named as KROX20, belongs to the EGR C2H2-type zinc-finger protein family. As a zinc finger transcription factor, it is observed in both the somata and dendrites of central neurons. EGR2 plays an important role in the transient formation of hindbrain developmental compartments or rhombomeres and is also an important factor in peripheral myelination, maintenance of synaptic plasticity and long-term potentiation. EGR2 expression is induced downstream of TCR signaling in NKT precursors and EGR2 is directly connected with the key molecular checkpoints defining NKT lineage commitment and stage progression, suggesting that EGR2 not only induces the early lineage-defining transcription factor PLZF, but also controls the downstream expression of the IL-2RB Beta chain. EGR2 is regulated by both soluble and membrane-bound neuregulins and its concentration is partially modulated by calcium-dependent events. EGR2/Krox20 is also required for induction of Pmp22, and is nuclear-localized.

Shipping Conditions:: Blue Ice