AN302046L
Recombinant SMARCB1/BAF47 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302046L
- Additional Names:
- MRD,SNF,CSS,INI,BAF,Snr,RTPS,PPP1R,SNF5L,SWNTS,SMARCB,SMARCB1,BAF47,CSS3,INI1,MRD15,PPP1R144,RDT,RTPS1,SNF5,SNF5L1,SWNTS1,Sfh1p,Snr1,hSNFS,BRG1-associated factor 47,hSNF5,Integrase interactor 1 protein,Malignant rhabdoid tumor suppressor,SNF5 homolog,Sucrose nonfermenting yeast homolog like 1,SWI/SNF complex component SNF5,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1,SWI10,Transcription factor TYE4,Transcription regulatory protein SNF5,TYE4
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Clone:
- A766
- Uniprot:
- Q12824
- Synonyms:
- BAF47;BRG1-associated factor 47;CSS3;hSNF5;hSNFS;INI1;integrase interactor 1 protein;malignant rhabdoid tumor suppressor;MRD15;PPP1R144;protein phosphatase 1, regulatory subunit 144;RDT;RTPS1;Sfh1p;SNF5;SNF5 homolog;SNF5L1;Snr1;sucrose nonfermenting, yeast, homolog-like 1;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1;SWI/SNF-related matrix-associated protein;SWNTS1
- Extra Details:
- ATP-dependent chromatin remodeling complexes play an essential role in the regulation of nuclear processes such as transcription and DNA replication and repair. The SWI/SNF chromatin remodeling complex consists of more than 10 subunits and contains a single molecule of either BRM or BRG1 as the ATPase catalytic subunit. The activity of the ATPase subunit disrupts histone-DNA contacts and changes the accessibility of crucial regulatory elements to the chromatin. The additional core and accessory subunits play a scaffolding role to maintain stability and provide surfaces for interaction with various transcription factors and chromatin. The interactions between SWI/SNF subunits and transcription factors, such as nuclear receptors, p53, Rb, BRCA1, and MyoD, facilitate recruitment of the complex to target genes for regulation of gene activation, cell growth, cell cycle, and differentiation processes.SMARCB1/BAF47, one of the core subunits of the SWI/SNF complex, is necessary for efficient nucleosome remodeling by BRG1 in vitro. SMARCB1/BAF47 is an essential part of the esBAF (mouse embryonic stem cell specific SWI/SNF complex) and is necessary for early embryogenesis and hepatocyte differentiation. In addition, SMARCB1/BAF47 is considered to be a tumor suppressor protein, inactivating mutations have been indentified in a large number of malignant rhabdoid tumors.
- Shipping Conditions:
- Blue Ice