AN302001L
Recombinant RON Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN302001L
- Additional Names:
- PTK,CDw,CD136,CDw136,PTK8,RON,MST1R,MSP-R,RON,CDw136
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Clone:
- A721
- Uniprot:
- Q04912
- Synonyms:
- c-met-related tyrosine kinase;CD136;CDw136;macrophage-stimulating protein receptor;MSP receptor;NPCA3;p185-Ron;Protein-tyrosine kinase 8;PTK8;PTK8 protein tyrosine kinase 8;RON;S13 avian erythroblastosis oncogene homolog;S13 erythroblastosis oncogene homolog;SEA
- Extra Details:
- Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa A Alpha chain and a 150 kDa B Beta chain. Ron is initially synthesized in the cells as a single-chain, pro Ron precursor that is cleaved into the two active chains. The A Alpha chain is completely extracellular, whereas the B Beta chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements. Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis.The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K)/Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival. The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors.
- Shipping Conditions:
- Blue Ice