AN301987L
Recombinant MYH7 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301987L
- Additional Names:
- CMH,MPD,MYH,myosin,MYH7,CMD1S,CMH1,MPD1,MYHCB,SPMD,SPMM,myosin-7,PVALB
- Application:
- IHC
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse, Rat
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Clone:
- A707
- Uniprot:
- P12883
- Synonyms:
- cardiac muscle myosin heavy chain 7 beta;CMD1S;CMH1;MPD1;myHC-beta;myhc-slow;MYHCB;myopathy, distal 1;myosin 7;Myosin heavy chain 7;myosin heavy chain beta-subunit;Myosin heavy chain slow isoform;Myosin heavy chain, cardiac muscle beta isoform;myosin-7;myosin, heavy chain 7, cardiac muscle, beta;myosin, heavy polypeptide 7, cardiac muscle, beta;rhabdomyosarcoma antigen MU-RMS-40.7A;SPMD;SPMM
- Extra Details:
- Nonmuscle myosin is an actin-based motor protein essential to cell motility, cell division, migration, adhesion, and polarity. The holoenzyme consists of two identical heavy chains and two sets of light chains. The light chains (MLCs) regulate myosin II activity and stability. The heavy chains (NMHCs) are encoded by three genes, MYH9, MYH10, and MYH14, which generate three different nonmuscle myosin II isoforms, IIa,IIb, and IIc, respectively. While all three isoforms perform the same enzymatic tasks, binding to and contracting actin filaments coupled to ATPhydrolysis, their cellular functions do not appear to be redundant and they have different subcellular distributions. The carboxy-terminal taildomain of myosin II is important in isoform-specific subcellular localization. Research studies have shown that phosphorylation of myosin IIa at Ser1943 contributes to the regulation of breast cancer cell migration.
- Shipping Conditions:
- Blue Ice