AN301986L
Recombinant SMC1A Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301986L
- Additional Names:
- SMC,CDLS,KIAA,SMC1L,SMC1A,CDLS2,DXS423E,SB1.8,SMC1,SMC1L1,SMC1alpha,SMCB,KIAA0178,Chromosome segregation protein SmcB,MGC138332,Segregation of mitotic chromosomes 1,SMC protein 1A,SMC1 (structural maintenance of chromosomes 1 yeast) like 1,SMC1 structural maintenance of chromosomes 1 like 1,SMC-1A,SMC-1-alpha,Structural maintenance of chromosomes 1A,Structural maintenance of chromosomes protein 1A
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human, Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Clone:
- A706
- Uniprot:
- Q14683
- Synonyms:
- CDLS2;DEE85;DXS423E;EIEE85;epididymis secretory sperm binding protein;SB1.8;segregation of mitotic chromosomes 1;SMC protein 1A;SMC-1-alpha;SMC1;SMC1 (structural maintenance of chromosomes 1, yeast)-like 1;SMC1alpha;SMC1L1;SMCB;structural maintenance of chromosomes protein 1A
- Extra Details:
- he cohesin complex consists of a heterodimer between SMC1 (SMC1A or B) and SMC3, bound by additional RAD21 and STAG proteins (STAG1, 2, or 3). These proteins form a ring-like structure that mediates the cohesion of two sister chromatids after DNA replication in S phase. RAD21 and STAG2 are phosphorylated by Polo-like kinase (PLK) during prophase, which leads to the dissociation of cohesin complexes from the chromosome arms, however, cohesin remains bound to centromeres until anaphase. RAD21 is cleaved by separin/ESPL1 in anaphase, which leads to dissociation of the remaining cohesin from centromeres, enabling sister chromatids to segregate during mitosis. RAD21 is also cleaved by caspase-3 and caspase-7 during apoptosis, resulting in a 64 kDa carboxy-terminal cleavage product that translocates to the cytoplasm and may help to trigger apoptosis. In addition to mediating cohesion of sister chromatids, the cohesin complex plays important roles in gene regulation and DNA repair, as SMC1 and SMC3 are both phosphorylated by ATM and ATR kinases upon DNA damage.
- Shipping Conditions:
- Blue Ice