Recombinant CD8 beta Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301982L
Additional Names:: LYT,LEU,CD8B,CD8B1,LEU2,LY3,LYT3,P37,T-Cell Surface Glycoprotein CD8 Beta Chain,CD8,Lyt3
Application:: IHC, WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Mouse
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Peptide. This information is proprietary to PTMab.
Clone:: A702
Uniprot:: P10966
Synonyms:: CD8 antigen, beta polypeptide 1 (p37);CD8B1;LEU2;LY3;LYT3;P37;T lymphocyte surface glycoprotein beta chain;T-cell surface glycoprotein CD8 beta chain
Extra Details:: Cluster of Differentiation 8 (CD8) is a disulphide-linked heterodimer consisting of the unrelated A Alpha and B Beta subunits. Each subunit is a glycoprotein composed of a single extracellular Ig-like domain, a polypeptide linker, a transmembrane part and a short cytoplasmic tail. On T cells, CD8 is the coreceptor for the T cell receptor (TCR), and these two distinct structures recognize the Antigen-Major Histocompatibility Complex (MHC). Specifically, the Ig-like domain of CD8A Alpha interacts with the A Alpha3-domain of the MHC class I molecule. CD8 ensures specificity of the TCR-antigen interaction, prolongs the contact between the T cell and the antigen presenting cell, and the A Alpha chain recruits the tyrosine kinase Lck, which is essential for T cell activation.