AN301972L
Recombinant GIRK2 Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301972L
- Additional Names:
- Girk,Girk2,Kcnj7,W,Kcnj6
- Application:
- WB
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Mouse
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Peptide. This information is proprietary to PTMab.
- Clone:
- A688
- Uniprot:
- P48542
- Synonyms:
- BIR1;G protein-activated inward rectifier potassium channel 2;G-protein-coupled inward rectifier K+ channel 2-1;G-protein-coupled inward rectifier K+ channel 2-A;G-protein-coupled inward rectifier K+ channel 2-B;G-protein-coupled inward rectifier K+ channel 2-C;GIR;GIRK-2;GIRK2;inward rectifier K(+) channel Kir3.2;KATP2;KCNJ;KCNJ7;Kir3;Kir3.2;potassium channel, inwardly rectifying subfamily J member 6;potassium inwardly-rectifying channel J6;weaver;wv
- Extra Details:
- GIRK2 is a member of G protein-coupled inwardly rectifying potassium channel family proteins (GIRKs). GIRK family proteins allow potassium to flow into the cell and therefore control cellular excitability in the central nervous system, heart, and pancreas. Activation of most GIRK channels requires heterologous subunit assembly and the presence of ATP. GIRK2 is abundantly expressed in the brain, where it is involved in pain perception. It is also required for peripheral opioid-mediated analgesia. Additionally GIRK2 localizes to pancreatic B Beta cells and regulates insulin secretion. Mutations in the KCNJ6 gene encoding GIRK2 are associated with Keppen-Lubinsky Syndrome, a rare disease characterized by severe developmental delay, facial dysmorphism, and intellectual disability.
- Shipping Conditions:
- Blue Ice