Recombinant SOX17 Monoclonal Antibody

Size

£252.90

Was £281.00

SKU:: AN301960L
Additional Names:: VUR,SOX,VUR3,SOX17
Application:: IHC, WB
Concentration:: 1 mg/ml
Purification:: Protein A Purified
Storage Conditions:: -20[o]C Avoid freeze/thaw cycles.
Supplier:: Elabscience
Host:: Rabbit
Reactivities:: Human
Buffer:: PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
Immunogen:: Recombinant human SOX17 fragment
Clone:: A676
Uniprot:: Q9H6I2
Synonyms:: SRY (sex determining region Y)-box 17;SRY-box 17;SRY-related HMG-box transcription factor SOX17;transcription factor SOX-17;VUR3
Extra Details:: SRY-related high mobility group box (SOX) proteins comprise a large family of widely conserved transcription factors. SOX proteins do not directly mediate transcription, but require binding partners that regulate their ability to mediate transcription of target genes that control cell fate determination and development .Transcription factor Sox17 is a Sox family protein with an established role in endoderm specification during development. In addition, Sox17 plays essential roles in the maintenance of the hematopoietic stem cell pool and for vascular morphogenesis during development. Sox17 negatively regulates oligodendrocyte precursor differentiation by antagonizing B Beta-catenin signaling. Mutation in the corresponding Sox17 gene in humans is associated with a form of vesicoureteral reflux, a disorder characterized by congenital kidney and urinary tract defects.