AN301943L
Recombinant RXRA Monoclonal Antibody
Size
£252.90
Was £281.00
- SKU:
- AN301943L
- Additional Names:
- NR2B,NR2B1,RXRA,Retinoid X receptor alpha
- Application:
- WB, IF
- Concentration:
- 1 mg/ml
- Purification:
- Protein A Purified
- Storage Conditions:
- -20[o]C Avoid freeze/thaw cycles.
- Supplier:
- Elabscience
- Host:
- Rabbit
- Reactivities:
- Human
- Buffer:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05% protein protectant.
- Immunogen:
- Recombinant human RXRA fragment
- Clone:
- A659
- Uniprot:
- P19793
- Synonyms:
- NR2B1;nuclear receptor subfamily 2 group B member 1;retinoic acid receptor RXR-alpha;retinoid X nuclear receptor alpha;Retinoid X receptor alpha
- Extra Details:
- Retinoid X receptor A Alpha (RXRA) is the founding RXR family member and is predominantly expressed in the liver, kidney, epidermis, intestine, and a variety of tissues. Knockout of the murine rxrA Alpha gene results in embryonic lethality tentatively due to myocardial hypoplasia, which demonstrates the importance of RXRA in retinoid signaling in vivo. Biochemical evidence suggests that RXRA transcriptional activity is post-translationally regulated through the Ras-Raf-MAPK signaling cascade. MAPK-dependent phosphorylation of RXRA Alpha directly abrogates the ability of RXRA to associate with nuclear receptor coactivators.
- Shipping Conditions:
- Blue Ice